LBC

The research group called Bioengineering and Chronobiology Laboratory, integrated in the atlanTTic group, works on the development and application of statistical methodology and signal processing, following a fundamentally practical and clinical approach, to improve the people’s health.

For more than 30 years, it has led projects and research projects in areas such as aging, epidemiology, oncology, pharmacology, endocrinology or the development of new methods of data analysis.

 

Research topics

  • Chronobiology and chronotherapy
  • Hypertension diagnoses
  • Cardiovascular, metabolic and renal risk assesment
  • Assessment of antihypertensive treatments
  • Early-detection of pre-eclampsia

 

Keywords

hypertension, diabetes, chronic renal disease, cardiovascular risk, pregnancy, ambulatory monitoring, circadian rhythms, chronobiology, chronotherapy, signal processing
 

Related research areas

 

Members

 

Contact information

Ramón Carmelo Hermida Domínguez

+34 986 812 148
rhermida@uvigo.es

 

Research results

Review
Hermida, R.C., Mojón, A., Hermida-Ayala, R.G., Smolensky, M.H., Fernández, J.R.
Extent of asleep blood pressure reduction by hypertension medications is ingestion-time dependent: Systematic review and meta-analysis of published human trials
Sleep Medicine Reviews, 59: 101454, 2021 | DOI

Review
Smolensky, M.H., Hermida, R.C., Geng, Y.-J.
Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes
Current Opinion in Pharmacology, 57: 41-48, 2021 | DOI

Review
Hermida, R.C., Hermida-Ayala, R.G., Smolensky, M.H., Mojón, A., Fernández, J.R.
Ingestion-time differences in the pharmacodynamics of hypertension medications: Systematic review of human chronopharmacology trials
Advanced Drug Delivery Reviews, 170: 200-213, 2021 | DOI

Review
Hermida, R.C., Mojón, A., Fernández, J.R., Otero, A., Crespo, J.J., Dominguez-Sardiña, M., Ríos, M.T., Smolensky, M.H.
Ambulatory blood pressure monitoring-based definition of true arterial hypertension
Minerva Medica, 111(6): 573-588, 2021 | DOI

Article
Hermida, R.C., Crespo, J.J., Domínguez-Sardiña, M., Otero, A., Moyá, A., Ríos, M.T., Sineiro, E., Castiñeira, M.C., Callejas, P.A., Pousa, L., Salgado, J.L., Durán, C., Sánchez, J.J., Fernández, J.R., Mojón, A., Ayala, D.E.
Bedtime hypertension treatment improves cardiovascular risk reduction: The Hygia Chronotherapy Trial
European Heart Journal, 41(48): 4565-4576, 2020 | DOI

Review
Hermida, R.C., Hermida-Ayala, R.G., Smolensky, M.H., Mojón, A., Fernández, J.R.
Ingestion-time–relative to circadian rhythms–differences in the pharmacokinetics and pharmacodynamics of hypertension medications
Expert Opinion on Drug Metabolism and Toxicology, 16(12): 1159-1173, 2020 | DOI

Review
Hermida, R.C., Hermida-Ayala, R.G., Smolensky, M.H., Mojón, A., Crespo, J.J., Otero, A., Ríos, M.T., Domínguez-Sardiña, M., Fernández, J.R.
Does Timing of Antihypertensive Medication Dosing Matter?
Current Cardiology Reports, 22(10): 118, 2020 | DOI

Article
Hermida, R.C., Mojón, A., Fernández, J.R.
Ambulatory blood pressure-based inclusion criteria in the Hygia Chronotherapy Trial. Rebuttal to Lemmer and Middeke
Chronobiology International, 37(8): 1270-1272, 2020 | DOI

Article
Hermida, R.C., Smolensky, M.H., Mojón, A., Crespo, J.J., Ríos, M.T., Domínguez-Sardiña, M., Otero, A., Fernández, J.R.
New perspectives on the definition, diagnosis, and treatment of true arterial hypertension
Expert Opinion on Pharmacotherapy, 21(10): 1167-1178, 2020 | DOI

Review
Hermida, R.C., Hermida-Ayala, R.G., Smolensky, M.
Chronotherapy for reduction of cardiovascular risk [Cronoterapia para reducción de riesgo cardiovascular]
Medicina Clinica, 154(12): 505-511, 2020 | DOI

Note
Hermida, R.C., Fernández, J.R., Mojón, A.
Chronotherapy of hypertension, asleep ambulatory blood pressure, and glaucoma
European Heart Journal, 41(16): 1605-, 2020 | DOI

Note
Hermida, R.C., Crespo, J.J., Domínguez-Sardiña, M.
Improved reduction of cardiovascular risk by bedtime ingestion of ARB and ACEI medication class therapies
European Heart Journal, 41(16): 1602-1603, 2020 | DOI

Note
Hermida, R.C., Mojón, A., Fernández, J.R.
Comparing the design of the primary-care based Hygia Chronotherapy Trial and the Internet-Based TIME Study
European Heart Journal, 41(16): 1608-, 2020 | DOI

Article
Fernández, J.R., Mojón, A., Hermida, R.C.
Chronotherapy of hypertension: advantages of 48-h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial
Chronobiology International, : 1-12, 2020 | DOI

Article
Hermida, R.C., Fernández, J.R., Mojón, A.
Current evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial
Chronobiology International, : 1-8, 2020 | DOI

Article
Hermida, R.C., Mojón, A., Fernández, J.R.
Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials
Chronobiology International, : 1-8, 2020 | DOI

Article
Crespo, J.J., Domínguez-Sardiña, M., Otero, A., Moyá, A., Ríos, M.T., Sineiro, E., Castiñeira, M.C., Callejas, P.A., Pousa, L., Salgado, J.L., Durán, C., Sánchez, J.J., Mojón, A., Fernández, J.R., Hermida, R.C.
Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials.
Chronobiology International, : 1-10, 2020 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Smolensky, M.H., Crespo, J.J., Otero, A., Domínguez-Sardiña, M., Moyá, A., Ríos, M.T., Castiñeira, M.C., Callejas, P.A., Pousa, L., Sineiro, E., Salgado, J.L., Durán, C., Sánchez, J.J., Fernández, J.R.
Cardiovascular disease risk stratification by the Framigham score is markedly improved by ambulatory compared with office blood pressure [La presión arterial ambulatoria, en comparación con la medida clínica, mejora notablemente la estratificación del riesgo cardiovascular de Framingham]
Revista Espanola de Cardiologia, : , 2020 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Smolensky, M.H., Fernández, J.R.
Diagnosis and management of hypertension: around-the-clock ambulatory blood pressure monitoring is substantially more effective and less costly than daytime office blood pressure measurements
Chronobiology International, 36(11): 1515-1527, 2019 | DOI

Note
Hermida, R.C.
Treatment of sleep-disordered breathing, alone, is insufficient for proper management of sleep-time hypertension
European Heart Journal, 40(38): 3208-, 2019 | DOI

Note
Hermida, R.C., Crespo, J.J., Otero, A., Domínguez-Sardiña, M., Moyá, A., Ríos, M.T., Castiñeira, M.C., Callejas, P.A., Pousa, L., Sineiro, E., Salgado, J.L., Durán, C., Sánchez, J.J., Fernández, J.R., Mojón, A., Ayala, D.E.
Asleep (not night-time) blood pressure as prognostic marker of cardiovascular risk
European Heart Journal, 40(9): 789-, 2019 | DOI

Article
Hermida, R.C., Crespo, J.J., Otero, A., Domínguez-Sardiña, M., Moyá, A., Ríos, M.T., Castiñeira, M.C., Callejas, P.A., Pousa, L., Sineiro, E., Salgado, J.L., Durán, C., Sánchez, J.J., Fernández, J.R., Mojón, A., Ayala, D.E.
Asleep blood pressure: Significant prognostic marker of vascular risk and therapeutic target for prevention
European Heart Journal, 39(47): 4159-4171, 2018 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Risk of incident chronic kidney disease is better reduced by bedtime than upon-awakening ingestion of hypertension medications article
Hypertension Research, 41(5): 342-353, 2018 | DOI

Review
Hermida, R.C., Ayala, D.E., Fernández, J.R., Mojón, A., Smolensky, M.H.
Hypertension: New perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk
European Journal of Clinical Investigation, 48(5): e12909, 2018 | DOI

Review
Smolensky, M.H., Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Bedtime Chronotherapy with Conventional Hypertension Medications to Target Increased Asleep Blood Pressure Results in Markedly Better Chronoprevention of Cardiovascular and Other Risks than Customary On-awakening Therapy
Heart Failure Clinics, 13(4): 775-792, 2017 | DOI

Review
Hermida, R.C., Ayala, D.E., Fernández, J.R., Mojón, A., Crespo, J.J., Ríos, M.T., Smolensky, M.H.
Bedtime Blood Pressure Chronotherapy Significantly Improves Hypertension Management
Heart Failure Clinics, 13(4): 759-773, 2017 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Sleep-time ambulatory BP is an independent prognostic marker of CKD
Journal of the American Society of Nephrology, 28(9): 2802-2811, 2017 | DOI

Review
Smolensky, M.H., Hermida, R.C., Reinberg, A., Sackett-Lundeen, L., Portaluppi, F.
Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention
Chronobiology International, 33(8): 1101-1119, 2016 | DOI

Article
Hermida, R.C.
Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: Rationale and design of the Hygia Project
Chronobiology International, 33(7): 906-936, 2016 | DOI

Review
Hermida, R.C., Ayala, D.E., Smolensky, M.H., Fernández, J.R., Mojón, A., Portaluppi, F.
Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks
Hypertension Research, 39(5): 277-292, 2016 | DOI

Letter
Hermida, R.C.
Reply [Respuesta]
Medicina Clinica, 146(1): 46-47, 2016 | DOI

Article
Hermida, R.C., Ayala, D.E.
Ambulatory blood pressure, chronotherapy of hypertension and glaucoma [Presión arterial ambulatoria, cronoterapia de la hipertensión y glaucoma]
Medicina Clinica, 146(1): 30-34, 2016 | DOI

Short Survey
Hermida, R.C., Moyá, A., Ayala, D.E.
Ambulatory blood pressure monitoring in diabetes for the assessment and control of vascular risk [Monitorización ambulatoria de la presión arterial en diabetes para valoración y control de riesgo vascular]
Endocrinologia y Nutricion, 62(8): 400-410, 2015 | DOI

Article
Hermida, R.C.
Chronotherapy with anti-hypertensive drugs to improve blood pressure control and reduce the vascular risk [Cronoterapia con antihipertensivos para mejorar el control de la presión arterial y reducir el riesgo vascular]
Medicina Clinica, 144(2): 62-64, 2015 | DOI

Letter
Smolensky, M.H., Ayala, D.E., Hermida, R.C.
Ambulatory Blood Pressure Monitoring (ABPM) as THE reference standard to confirm diagnosis of hypertension in adults: Recommendation of the 2015 U.S. Preventive Services Task Force (USPSTF)
Chronobiology International, 32(9): 1320-1322, 2015 | DOI

Review
Hermida, R.C., Smolensky, M.H., Ayala, D.E., Portaluppi, F.
Ambulatory Blood Pressure Monitoring (ABPM) as the reference standard for diagnosis of hypertension and assessment of vascular risk in adults
Chronobiology International, 32(10): 1329-1342, 2015 | DOI

Article
Smolensky, M.H., Hermida, R.C., Ayala, D.E., Portaluppi, F.
Bedtime hypertension chronotherapy: Concepts and patient outcomes
Current Pharmaceutical Design, 21(6): 773-790, 2015 | DOI

Article
Hermida, R.C., Ayala, D.E., Ríos, M.T., Fernández, J.R., Mojón, A., Smolensky, M.H.
Around-the-clock ambulatory blood pressure monitoring is required to properly diagnose resistant hypertension and assess associated vascular risk
Current Hypertension Reports, 16(7): 445, 2014 | DOI

Article
Hermida, R.C., Ayala, D.E., Smolensky, M.H., Fernández, J.R., Mojón, A., Crespo, J.J., Ríos, M.T., Moyá, A., Portaluppi, F.
Chronotherapeutics of conventional blood pressure-lowering medications: Simple, low-cost means of improving management and treatment outcomes of hypertensive-related disorders topical collection on antihypertensive agents: Mechanisms of drug action
Current Hypertension Reports, 16(2): 412, 2014 | DOI

Review
Hermida, R.C., Ayala, D.E., Mojón, A., Smolensky, M.H., Portaluppi, F., Fernández, J.R.
Sleep-time ambulatory blood pressure as a novel therapeutic target for cardiovascular risk reduction
Journal of Human Hypertension, 28(10): 567-574, 2014 | DOI

Article
Hermida, R.C., Ayala, D.E., Ríos, M.T., Fernández, J.R., Mojón, A., Smolensky, M.H.
Around-the-clock ambulatory blood pressure monitoring is required to properly diagnose resistant hypertension and assess associated vascular risk
Current Hypertension Reports, 16(7): 445, 2014 | DOI

Review
Hermida, R.C., Smolensky, M.H., Ayala, D.E., Fernández, J.R., Moyá, A., Crespo, J.J., Mojón, A., Ríos, M.T., Fabbian, F., Portaluppi, F.
Abnormalities in chronic kidney disease of ambulatory blood pressure 24 h patterning and normalization by bedtime hypertension chronotherapy
Nephrology Dialysis Transplantation, 29(6): 1160-1167, 2014 | DOI

Review
Roush, G.C., Fagard, R.H., Salles, G.F., Pierdomenico, S.D., Reboldi, G., Verdecchiaf, P., Eguchi, K., Kario, K., Hoshide, S., Polonia, J., De La Sierra, A., Hermida, R.C., Dolank, E., Zamallo, H.
Prognostic impact from clinic, daytime, and nighttime systolic blood pressure in nine cohorts of 13844 patients with hypertension
Journal of Hypertension, 32(12): 2332-2340, 2014 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Ambulatory blood pressure thresholds for diagnosis of hypertension in patients with and without type 2 diabetes based on cardiovascular outcomes
Chronobiology International, 30(01/02/2021 0:00): 132-144, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Fontao, M.J., Mojón, A., Fernández, J.R.
Ambulatory blood pressure monitoring: Importance of sampling rate and duration-48 versus 24 hours-on the accurate assessment of cardiovascular risk
Chronobiology International, 30(01/02/2021 0:00): 55-67, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fontao, M.J., Chayán, L., Fernández, J.R.
Differences between men and women in ambulatory blood pressure thresholds for diagnosis of hypertension based on cardiovascular outcomes
Chronobiology International, 30(01/02/2021 0:00): 221-232, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Crespo, J.J., Mojón, A., Chayán, L., Fontao, M.J., Fernández, J.R.
Influence of age and hypertension treatment-time on ambulatory blood pressure in hypertensive patients
Chronobiology International, 30(01/02/2021 0:00): 176-191, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Fernández, J.R., Mojón, A., Smolensky, M.H., Fabbian, F., Portaluppi, F.
Administration-Time Differences in Effects of Hypertension Medications on Ambulatory Blood Pressure Regulation
Chronobiology International, 30(01/02/2021 0:00): 280-314, 2013 | DOI

Article
Crespo, J.J., Piñeiro, L., Otero, A., Castiñeira, C., Ríos, M.T., Regueiro, A., Mojón, A., Lorenzo, S., Ayala, D.E., Hermida, R.C.
Administration-time-dependent effects of hypertension treatment on ambulatory blood pressure in patients with chronic kidney disease
Chronobiology International, 30(01/02/2021 0:00): 159-175, 2013 | DOI

Article
Ayala, D.E., Moyá, A., Crespo, J.J., Castiñeira, C., Domínguez-Sardiña, M., Gomara, S., Sineiro, E., Mojón, A., Fontao, M.J., Hermida, R.C.
Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes
Chronobiology International, 30(01/02/2021 0:00): 99-115, 2013 | DOI

Article
Moyá, A., Crespo, J.J., Ayala, D.E., Ríos, M.T., Pousa, L., Callejas, P.A., Salgado, J.L., Mojón, A., Fernández, J.R., Hermida, R.C.
Effects of time-of-day of hypertension treatment on ambulatory blood pressure and clinical characteristics of patients with type 2 diabetes
Chronobiology International, 30(01/02/2021 0:00): 116-131, 2013 | DOI

Article
Ríos, M.T., Domínguez-Sardiña, M., Ayala, D.E., Gomara, S., Sineiro, E., Pousa, L., Callejas, P.A., Fontao, M.J., Fernández, J.R., Hermida, R.C.
Prevalence and clinical characteristics of isolated-office and true resistant hypertension determined by ambulatory blood pressure monitoring
Chronobiology International, 30(01/02/2021 0:00): 207-220, 2013 | DOI

Article
Mojón, A., Ayala, D.E., Piñeiro, L., Otero, A., Crespo, J.J., Moyá, A., Bóveda, J., De Lis, J.P., Fernández, J.R., Hermida, R.C.
Comparison of ambulatory blood pressure parameters of hypertensive patients with and without chronic kidney disease
Chronobiology International, 30(01/02/2021 0:00): 145-158, 2013 | DOI

Article
Hermida, R.C., Ríos, M.T., Crespo, J.J., Moyá, A., Domínguez-Sardiña, M., Otero, A., Sánchez, J.J., Mojón, A., Fernández, J.R., Ayala, D.E.
Treatment-time regimen of hypertension medications significantly affects ambulatory blood pressure and clinical characteristics of patients with resistant hypertension
Chronobiology International, 30(01/02/2021 0:00): 192-206, 2013 | DOI

Letter
Portaluppi, F., Smolensky, M., Ayala, D.E., Hermida, R.C.
Nondipping and cardiovascular risk after morning renin-angiotensin blockade
Hypertension, 61(2): , 2013 | DOI

Article
Ayala, D.E., Ucieda, R., Hermida, R.C.
Chronotherapy with low-dose aspirin for prevention of complications in pregnancy
Chronobiology International, 30(01/02/2021 0:00): 260-279, 2013 | DOI

Article
Smolensky, M.H., Sackett-Lundeen, L.L., Reinberg, A.E., Touitou, Y., Hermida, R.C.
Erhard Haus (September 8, 1926 to June 14, 2013).
Chronobiology international, 30(8): 1072-1075, 2013 | DOI

Letter
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R., Smolensky, M., Portaluppi, F.
Morning surge, dipping, and sleep-time blood pressure as prognostic markers of cardiovascular risk
Hypertension, 61(1): , 2013 | DOI

Review
Hermida, R.C., Ayala, D.E., Smolensky, M.H., Mojón, A., Fernández, J.R., Crespo, J.J., Moyá, A., Ríos, M.T., Portaluppi, F.
Chronotherapy improves blood pressure control and reduces vascular risk in CKD
Nature Reviews Nephrology, 9(6): 358-368, 2013 | DOI

Letter
Hermida, R.C., Ayala, D.E., Smolensky, M.H., Mojón, A., Fernández, J.R., Portaluppi, F.
Asleep blood pressure: Relevance to the proper definition of isolated-office and masked hypertension
Hypertension Research, 36(5): 471-472, 2013 | DOI

Article
Hermida, R.C., Smolensky, M.H., Ayala, D.E., Portaluppi, F., Crespo, J.J., Fabbian, F., Haus, E., Manfredini, R., Mojón, A., Moyá, A., Piñeiro, L., Ríos, M.T., Otero, A., Balan, H., Fernández, J.R.
2013 Ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension-associated risk, and attainment of therapeutic goals (summary). Joint recommendations from the International Society for Chronobiology (ISC), American Association of Medical Chronobiology and Chronotherapeutics (AAMCC), Spanish Society of Applied Ch
Clinica e Investigacion en Arteriosclerosis, 25(2): 74-82, 2013 | DOI

Review
Hermida, R.C., Smolensky, M.H., Ayala, D.E., Portaluppi, F., Crespo, J.J., Fabbian, F., Haus, E., Manfredini, R., Mojón, A., Moyá, A., Piñeiro, L., Ríos, M.T., Otero, A., Balan, H., Fernández, J.R.
2013 ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension-associated risk, and attainment of therapeutic goals
Chronobiology International, 30(3): 355-410, 2013 | DOI

Article
Ayala, D.E., Hermida, R.C.
Ambulatory blood pressure monitoring for the early identification of hypertension in pregnancy
Chronobiology International, 30(01/02/2021 0:00): 233-259, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Fernández, J.R., Mojón, A.
Sleep-time blood pressure: Prognostic value and relevance as a therapeutic target for cardiovascular risk reduction
Chronobiology International, 30(01/02/2021 0:00): 68-86, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Cardiovascular risk of essential hypertension: Influence of class, number, and treatment-time regimen of hypertension medications
Chronobiology International, 30(01/02/2021 0:00): 315-327, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Blunted sleep-time relative blood pressure decline increases cardiovascular risk independent of blood pressure level-The "Normotensive Non-dipper" paradox
Chronobiology International, 30(01/02/2021 0:00): 87-98, 2013 | DOI

Article
Ayala, D.E., Hermida, R.C., Mojón, A., Fernández, J.R.
Cardiovascular risk of resistant hypertension: Dependence on treatment-time regimen of blood pressure-lowering medications
Chronobiology International, 30(01/02/2021 0:00): 340-352, 2013 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Role of time-of-day of hypertension treatment on the J-shaped relationship between blood pressure and cardiovascular risk
Chronobiology International, 30(01/02/2021 0:00): 328-339, 2013 | DOI

Article
Hermida, R.C.
Use of = 1 antihypertensive drug at bedtime reduced CV events more than use of all drugs in the morning in CKD
Annals of Internal Medicine, 156(12): JC6-JC8, 2012 | DOI

Review
Portaluppi, F., Tiseo, R., Smolensky, M.H., Hermida, R.C., Ayala, D.E., Fabbian, F.
Circadian rhythms and cardiovascular health
Sleep Medicine Reviews, 16(2): 151-166, 2012 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Sleep-time blood pressure and the prognostic value of isolated-office and masked hypertension
American Journal of Hypertension, 25(3): 297-305, 2012 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Sleep-time blood pressure as a therapeutic target for cardiovascular risk reduction in type 2 diabetes
American Journal of Hypertension, 25(3): 325-334, 2012 | DOI

Book Chapter
Smolensky, M.H., Siegel, R.A., Haus, E., Hermida, R., Portaluppi, F.
Biological rhythms, drug delivery, and chronotherapeutics
Fundamentals and Applications of Controlled Release Drug Delivery, : 359-443, 2012 | DOI

Note
Hermida, R.C., Ayala, D.E., Mojón, A., Fernandez, J.R.
Response to comment on: Hermida et al. Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes. Diabetes Care 2011;34: 1270-1276
Diabetes Care, 34(12): , 2011 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Bedtime dosing of antihypertensive medications reduces cardiovascular risk in CKD
Journal of the American Society of Nephrology, 22(12): 2313-2321, 2011 | DOI

Letter
Ayala, D.E., Hermida, R.C., Portaluppi, F., Smolensky, M.H.
Bedtime hypertension treatment increases ambulatory blood pressure control and reduces cardiovascular risk in resistant hypertension
Hypertension, 58(4): , 2011 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Decreasing sleep-time blood pressure determined by ambulatory monitoring reduces cardiovascular risk
Journal of the American College of Cardiology, 58(11): 1165-1173, 2011 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fontao, M.J., Fernández, J.R.
Chronotherapy with valsartan/hydrochlorothiazide combination in essential hypertension: Improved sleep-time blood pressure control with bedtime dosing
Chronobiology International, 28(7): 601-610, 2011 | DOI

Article
Hermida, R.C., Chayán, L., Ayala, D.E., Mojón, A., Fontao, M.J., Fernández, J.R.
Relationship between metabolic syndrome, circadian treatment time, and blood pressure non-dipping profile in essential hypertension
Chronobiology International, 28(6): 509-519, 2011 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojon, A., Fernandez, J.R.
Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patientswith type 2 diabetes
Diabetes Care, 34(6): 1270-1276, 2011 | DOI

Article
Hermida, R.C., Ayala, D.E., Fernández, J.R., Portaluppi, F., Fabbian, F., Smolensky, M.H.
Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications
American Journal of Hypertension, 24(4): 383-391, 2011 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Influence of circadian time of hypertension treatment on cardiovascular risk: Results of the MAPEC study
Chronobiology International, 27(8): 1629-1651, 2010 | DOI

Review
Smolensky, M.H., Hermida, R.C., Ayala, D.E., Tiseo, R., Portaluppi, F.
Administration-time-dependent effects of blood pressure-lowering medications: Basis for the chronotherapy of hypertension
Blood Pressure Monitoring, 15(4): 173-180, 2010 | DOI

Article
Hermida, R.C., Ayala, D.E., Fontao, M.J., Mojón, A., Fernndez, J.R.
Chronotherapy with valsartan/amlodipine fixed combination: Improved blood pressure control of essential hypertension with bedtime dosing
Chronobiology International, 27(6): 1287-1303, 2010 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Effects of time of antihypertensive treatment on ambulatory blood pressure and clinical characteristics of subjects with resistant hypertension
American Journal of Hypertension, 23(4): 432-439, 2010 | DOI

Article
Hermida, R.C., Ayala, D.E., Fontao, M.J., Mojn, A., Alonso, I., Fernndez, J.R.
Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension
Chronobiology International, 27(3): 560-574, 2010 | DOI

Article
Ayala, D.E., Hermida, R.C.
Sex differences in the administration-time-dependent effects of low-dose aspirin on ambulatory blood pressure in hypertensive subjects
Chronobiology International, 27(2): 345-362, 2010 | DOI

Letter
Hermida, R.C., Ayala, D.E.
Prognostic value of ambulatory blood pressure monitoring in pregnancy
Journal of Hypertension, 28(5): 1110-1111, 2010 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Ambulatory blood pressure control with bedtime aspirin administration in subjects with prehypertension
American Journal of Hypertension, 22(8): 896-903, 2009 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Alonso, I., Fernández, J.R.
Reduction of morning blood pressure surge after treatment with nifedipine GITS at bedtime, but not upon awakening, in essential hypertension
Blood Pressure Monitoring, 14(4): 152-159, 2009 | DOI

Article
Ayala, D.E., Hermida, R.C., Chayán, L., Mojón, A., Fontao, M.J., Fernández, J.R.
Circadian pattern of ambulatory blood pressure in untreated hypertensive tatients with and without metabolic syndrome
Chronobiology International, 26(6): 1189-1205, 2009 | DOI

Article
Hermida, R.C., Ayala, D.E.
Chronotherapy with the angiotensin-converting enzyme inhibitor ramipril in essential hypertension: Improved blood pressure control with bedtime dosing
Hypertension, 54(1): 40-46, 2009 | DOI

Article
Cabezas-Cerrato, J., Hermida, R.C., Cabezas-Agrícola, J.M., Ayala, D.E.
Cardiac autonomic neuropathy, estimated cardiovascular risk, and circadian blood pressure pattern in diabetes mellitus
Chronobiology International, 26(5): 942-957, 2009 | DOI

Article
Hermida, R.C., Chayán, L., Ayala, D.E., Mojón, A., Domínguez, M.J., Fontao, M.J., Soler, R., Alonso, I., Fernández, J.R.
Association of metabolic syndrome and blood pressure nondipping profile in untreated hypertension
American Journal of Hypertension, 22(3): 307-313, 2009 | DOI

Article
Fernandez, J.R., Hermida, R.C., Mojon, A.
Chronobiological analysis techniques. application to blood pressure
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 367(1887): 431-445, 2009 | DOI

Article
Hermida, R.C., Ayala, D.E., Chayán, L., Mojón, A., Fernández, J.R.
Administration-time-dependent effects of olmesartan on the ambulatory blood pressure of essential hypertension patients
Chronobiology International, 26(1): 61-79, 2009 | DOI

Book Chapter
Halberg, F., Cornélissen, G., Singh, R.B., Gvozdjáková, A., Otsuka, K., Beaty, L., Katinas, G., Hermida, R., Ayala, D., Czaplicki, J.
Chronobiology, chronomics and N-of-1 tests of timing coenzyme Q10
Mitochondrial Medicine: Mitochondrial Metabolism, Diseases, Diagnosis and Therapy, : 55-92, 2008 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Chayán, L., Domínguez, M.J., Fontao, M.J., Soler, R., Alonso, I., Fernández, J.R.
Comparison of the effects on ambulatory blood pressure of awakening versus bedtime administration of torasemide in essential hypertension
Chronobiology International, 25(6): 950-970, 2008 | DOI

Article
Hermida, R.C., Ayala, D.E., Mojón, A., Fernández, J.R.
Chronotherapy with nifedipine GITS in hypertensive patients: Improved efficacy and safety with bedtime dosing
American Journal of Hypertension, 21(8): 948-954, 2008 | DOI

Article
Hermida, R.C., Ayala, D.E., Khder, Y., Calvo, C.
Ambulatory blood pressure-lowering effects of valsartan and enalapril after a missed dose in previously untreated patients with hypertension: A prospective, randomized, open-label, blinded end-point trial
Clinical Therapeutics, 30(1): 108-120, 2008 | DOI

Article
Hermida, R.C., Ayala, D.E., Fernández, J.R., Calvo, C.
Chronotherapy improves blood pressure control and reverts the nondipper pattern in patients with resistant hypertension
Hypertension, 51(1): 69-76, 2008 | DOI

Article
Kanabrocki, E.L., Ryan, M.D., Hermida, R.C., Ayala, D.E., McCormick, J.B., Dawson, S., Lojo, L., Hoffman, H.S., Siegel, G., Friedman, N., Eladasori, B., Parachuri, R., Nemchausky, B.A.
Uric acid and renal function in Multiple Sclerosis
Clinica Terapeutica, 159(1): 35-40, 2008 | DOI

Conference Paper
Hermida, R.C., Ayala, D.E., Fernández, J.R., Calvo, C.
Comparison of the efficacy of morning versus evening administration of telmisartan in essential hypertension
Hypertension, 50(4): 715-722, 2007 | DOI

Article
Smolensky, M.H., Hermida, R.C., Castriotta, R.J., Portaluppi, F.
Role of sleep-wake cycle on blood pressure circadian rhythms and hypertension
Sleep Medicine, 8(6): 668-680, 2007 | DOI

Review
Portaluppi, F., Hermida, R.C.
Circadian rhythms in cardiac arrhythmias and opportunities for their chronotherapy
Advanced Drug Delivery Reviews, 59(09/10/2021 0:00): 940-951, 2007 | DOI

Review
Hermida, R.C., Ayala, D.E., Portaluppi, F.
Circadian variation of blood pressure: The basis for the chronotherapy of hypertension
Advanced Drug Delivery Reviews, 59(09/10/2021 0:00): 904-922, 2007 | DOI

Review
Hermida, R.C., Ayala, D.E., Calvo, C., Portaluppi, F., Smolensky, M.H.
Chronotherapy of hypertension: Administration-time-dependent effects of treatment on the circadian pattern of blood pressure
Advanced Drug Delivery Reviews, 59(09/10/2021 0:00): 923-939, 2007 | DOI

Review
Smolensky, M.H., Hermida, R.C., Portaluppi, F., Haus, E.
Twenty-four-hour pattern of angina pectoris, acute myocardial infarction and sudden cardiac death: Role of blood pressure, heart rate and rate-pressure product circadian rhythms
Biological Rhythm Research, 38(3): 205-216, 2007 | DOI

Article
Hermida, R.C., Calvo, C., Ayala, D.E., López, J.E., Rodríguez, M., Chayán, L., Mojón, A., Fontao, M.J., Fernández, J.R.
Dose- and administration time-dependent effects of nifedipine gits on ambulatory blood pressure in hypertensive subjects
Chronobiology International, 24(3): 471-493, 2007 | DOI

Review
Hermida, R.C.
Ambulatory blood pressure monitoring in the prediction of cardiovascular events and effects of chronotherapy: Rationale and design of the MAPEC study
Chronobiology International, 24(4): 749-775, 2007 | DOI

Review
Hermida, R.C., Ayala, D.E., Calvo, C.
Optimal timing for antihypertensive dosing: Focus on valsartan
Therapeutics and Clinical Risk Management, 3(1): 119-131, 2007 | DOI

Article
Smolensky, M.H., Hermida, R.C., Portaluppi, F.
Comparison of the efficacy of morning versus evening administration of olmesartan in uncomplicated essential hypertension
Chronobiology International, 24(1): 171-181, 2007 | DOI

Review
Hermida, R.C., Ayala, D.E., Smolensky, M.H., Portaluppi, F.
Chronotherapy in hypertensive patients: Administration-time dependent effects of treatment on blood pressure regulation
Expert Review of Cardiovascular Therapy, 5(3): 463-475, 2007 | DOI

Article
Hermida, R.C., Ayala, D.E., Fernández, J.R., Mojón, A., Calvo, C.
Influence of measurement duration and frequency on ambulatory blood pressure monitoring [Influencia de la duración y la frecuencia de muestreo en la medición ambulatoria de la presión arterial]
Revista Espanola de Cardiologia, 60(2): 131-138, 2007 | DOI

Article
Calvo, C., Hermida, R.C., Ayala, D.E., López, J.E., Rodríguez, M., Chayán, L., Mojón, A., Soler, R., Fontao, M.J., Fernández, J.R.
Chronotherapy with torasemide in hypertensive patients: Increased efficacy and therapeutic coverage with bedtime administration [Cronoterapia con torasemida en pacientes hipertensos: Aumento de la duración y la eficacia terapéuticas con su administración a la hora de acostarse]
Medicina Clinica, 127(19): 721-729, 2006 | DOI

Article
Schiedermaier, P., Koch, L., Mojón, A., Hermida, R., Layer, G., Sauerbruch, T.
Circadian rhythm of fasting and postprandial portal blood flow in cirrhosis
Scandinavian Journal of Gastroenterology, 41(7): 826-832, 2006 | DOI

Article
Kanabrocki, E.L., Hermida, R.C., Torossov, M., Haseman, M.B., Bettis, K., Young, R.M.I., Mathew, J.P., Potkul, R., Hrushesky, W.J.M.
Chronotherapy of ovarian cancer: Effect on blood variables and serum cytokines. A case report
Clinica Terapeutica, 157(4): 349-354, 2006 | DOI

Article
Aboy, M., Fernández, J.R., Hermida, R.C.
The population RDH index: A novel vector index and graphical method for statistical assessment of antihypertensive treatment reduction, duration, and homogeneity
Blood Pressure Monitoring, 11(3): 143-155, 2006 | DOI

Article
Kanabrocki, E.L., Vesely, D.L., Hermida, R.C., Ayala, D.E., Ryan, M.D., Burden, J., Shah, F., Friedman, N.C., Eladasari, B., Nemchausky, B.A., Dawson, S., McCormick, J.B., Alessandrini, S.M., Hooper, D.C.
Circadian distribution of hematology variables in subjects with multiple sclerosis
Clinica Terapeutica, 157(3): 241-247, 2006 | DOI

Article
Aboy, M., Fernández, J.R., McNames, J., Hermida, R.C.
The individual RDH index: A novel vector index for statistical assessment of antihypertensive treatment reduction, duration, and homogeneity
Blood Pressure Monitoring, 11(2): 69-78, 2006 | DOI

Article
Calvo, C., Hermida, R.C., Ayala, D.E., López, J.E., Fernández, J.R., Mojón, A., Covelo, M.
Effects of time-dependent administration of antihypertensive treatment in patients with resistant hypertension [Efectos de la administración temporalizada de fármacos antihipertensivos en pacientes con hipertensión arterial resistente]
Medicina Clinica, 126(10): 364-372, 2006 | DOI

Article
Calvo, C., Hermida, R.C.
What impact will chronobiology have in the future guidelines of cardiovascular risk? [¿Qué impacto tendrá la cronobiología en las futuras guías de riesgo cardiovascular?]
Medicina Clinica Monografias, 6(2): 75-78, 2005 | DOI

Editorial
Calvo, C., Hermida, R.C.
Introduction: Chronobiology and cardiovascular disease [Introducción: Cronobiología y enfermedad cardiovascular]
Medicina Clinica Monografias, 6(2): 1-3, 2005 | DOI

Article
Hermida, R.C., Calvo, C., Tamargo, J.
Antihypertensive drugs and chronotherapy [Fármacos antihipertensivos y cronoterapia]
Medicina Clinica Monografias, 6(2): 45-57, 2005 | DOI

Article
Hermida, R.C., Ayala, D.E., López, J.E.
Modifications in the circadian variation of arterial pressure [Modificaciones en la variación circadiana de la presión arterial]
Medicina Clinica Monografias, 6(2): 29-37, 2005 | DOI

Article
Hermida, R.C., Calvo, C., Ayala, D.E.
Angiotensin receptor antagonists II and chronotherapy [Antagonistas de los receptores de la angiotensina II y cronoterapia]
Medicina Clinica Monografias, 6(2): 58-64, 2005 | DOI

Article
Smolensky, M.H., Haus, E., Hermida, R.C., Portaluppi, F.
Circadian pattern in case of cardiac and cerebrovascular episodes [Patrón circadiano en la incidencia de episodios cardíacos y cerebrovasculares]
Medicina Clinica Monografias, 6(2): 11-16, 2005 | DOI

Book Chapter
Smolensky, M.H., Hermida, R.C., Portaluppi, F., Haus, E., Reinberg, A.
Chronotherapeutics in the Treatment of Hypertension
Hypertension, : 530-542, 2005 | DOI

Article
Hermida, R.C., Ayala, D.E., Calvo, C., López, J.E.
Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients
Journal of the American College of Cardiology, 46(6): 975-983, 2005 | DOI

Article
Hermida, R.C., Ayala, D.E.
Circadian blood pressure variability in normotensive pregnant women as a function of parity, maternal age, and stage of gestation
Chronobiology International, 22(2): 321-341, 2005 | DOI

Review
Aboy, M., Fernández, J.R., Hermida, R.C.
Methodological considerations in the evaluation of the duration of action of antihypertensive therapy using ambulatory blood pressure monitoring
Blood Pressure Monitoring, 10(3): 111-115, 2005 | DOI

Review
Caeiro Muñoz, M., Calderón González, A., Mojón Ojea, A., López Lóuzara, M.L., Fernández Bernárdez, J.R., Alonso Alonso, I., Vázquez De La Torre, M.L., Rodríguez Cerdeiro, C., Muñoz Garzón, V.M., Hermida Domínguez, R.C.
Role of hyperbaric oxygen therapy for the treatment of the chronic complications derived from radiation therapy in cancer patients. Physical, technical and clinical bases [Papel de la oxigenoterapia hiperbárica en el tratamiento de las complicaciones crónicas derivadas del tratamiento con radioterapia en pacientes con cáncer. Bases físicas, técnicas y clínicas]
Oncologia, 28(1): 26-35, 2005 | DOI

Conference Paper
Martínez-Rey, C., Otero-Antón, E., Tomé, S., Rodríguez-Framil, M., González-Quintela, A., Calvo, C., Hermida, R.C., Ayala, D., Varo, E.
Circadian variability of blood pressure in liver transplant recipients without antihypertensive therapy
Transplantation Proceedings, 37(3): 1515-1516, 2005 | DOI

Letter
Désola, J., Hermida, R.C., Ayala, D.E., Iglesias, M.
Hyperbaric tolerance test. Conceptual remarks [3] (multiple letters) [Test de tolerancia hiperbárica. Precisiones terminológicas y conceptuales]
Medicina Clinica, 124(8): 316-31784347, 2005 | DOI

Note
Hermida, R.C.
Commentary
Evidence-based Cardiovascular Medicine, 9(1): 9-10, 2005 | DOI

Article
Hermida, R.C., Ayala, D.E.
Reference thresholds for 24-h, diurnal, and nocturnal ambulatory blood pressure mean values in pregnancy
Blood Pressure Monitoring, 10(1): 33-41, 2005 | DOI

Review
Hermida, R.C., Ayala, D.E., Calvo, C.
Administration-time-dependent effects of antihypertensive treatment on the circadian pattern of blood pressure
Current Opinion in Nephrology and Hypertension, 14(5): 453-459, 2005 | DOI

Article
Hermida, R.C., Calvo, C., Ayala, D.E., López, J.E.
Decrease in urinary albumin excretion associated with the normalization of nocturnal blood pressure in hypertensive subjects.
Hypertension, 46(4): 960-968, 2005 | DOI

Review
Smolensky, M.H., Hermida, R.C., Haus, E., Portaluppi, F., Reinberg, A.
Biological rhythms, medication safety, and women's health
Journal of Women's Health, 14(1): 38-46, 2005 | DOI

Article
Hermida, R.C., Ayala, D.E., Calvo, C., López, J.E., Mojón, A., Rodríguez, M., Fernández, J.R.
Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensives.
Hypertension, 46(4): 1060-1068, 2005 | DOI

Article
Hermida, R.C., Calvo, C., Ayala, D.E., Fernández, J.R., Covelo, M., Mojón, A., López, J.E.
Treatment of non-dipper hypertension with bedtime administration of valsartan
Journal of Hypertension, 23(10): 1913-1922, 2005 | DOI

Article
Hermida, R.C., Ayala, D.E., Calvo, C., López, J.E., Mojón, A., Fontao, M.J., Soler, R., Fernández, J.R.
Effects of time of day of treatment on ambulatory blood pressure pattern of patients with resistant hypertension.
Hypertension, 46(4): 1053-1059, 2005 | DOI

Article
Hermida, R.C., Calvo, C., Ayala, D.E., Mojón, A., Rodríguez, M., Chayán, L., López, J.E., Fontao, M.J., Soler, R., Fernández, J.R.
Administration time-dependent effects of valsartan on ambulatory blood pressure in elderly hypertensive subjects
Chronobiology International, 22(4): 755-776, 2005 | DOI

Article
Hermida, R.C., Calvo, C., Ayala, D.E., López, J.E., Fernández, J.R., Mojón, A., Domínguez, M.J., Covelo, M.
Seasonal variation of fibrinogen in hypertensive patients
Cardiology Review, 21(11): 38-41, 2004 | DOI

Article
Kanabrocki, E.L., Ryan, M.D., Hermida, R.C., Ayala, D.E., Scott, G.S., Murray, D., Bremner, W.F., Third, J.L.H.C., Johnson, M.C., Foley, S., Van Cauteren, J., Shah, F., Shirazi, P., Nemchausky, B.A., Hooper, D.C.
Altered circadian relationship between serum nitric oxide, carbon dioxide, and uric acid in multiple sclerosis
Chronobiology International, 21(04/05/2021 0:00): 739-758, 2004 | DOI

Review
Hermida, R.C., Smolensky, M.H.
Chronotherapy of hypertension
Current Opinion in Nephrology and Hypertension, 13(5): 501-505, 2004 | DOI

Article
Hermida, R.C., Ayala, D.E., Iglesias, M.
Differences in circadian pattern of ambulatory pulse pressure between healthy and complicated pregnancies
Hypertension, 44(3): 316-321, 2004 | DOI

Article
Fernández, J.R., Mojón, A., Hermida, R.C.
Comparison of parameters from rhythmometric models with multiple compon